Math Puzzle 4

Puzzle 1: Which number replaces the question mark?

Puzzle 2: Which number replaces the question mark?

3, 5, 13, 43, 177, ?, 5353

Puzzle 3: Which number replaces the question mark?

Puzzle 4: Which number replaces the question mark?

If 2 + 3 = 8

3 + 7 = 27

4 + 5 = 32

5 + 8 = 60

6 + 7 = 72

Then 7 + 8 =?